projects
3.1 million Americans
LIVE WITH INFLAMMATORY BOWEL DISEASE
Crohn's disease and ulcerative colitis affect 1.3% of the population with 70,000 new cases diagnosed every year. IBD is caused by a combination of genetic and environmental factors that lead to an abnormal immune reaction to the normal bacteria found in the intestine.
news
Although we will miss Irving at Sinai, we could not be more excited for him as he starts his new faculty position in the Center for Microbiological Research at Universidad Autónoma de Guerrero (MX) where he'll continue to study γδ IELs.
October 2025
We are looking for a recent PhD graduate with experience in T cell biology or GI mucosal immunology to join our group! This is an NIH funded position focused on the role of IELs in Crohn's disease. Expertise in high-dimensional flow cytometry strongly preferred.
October 2025
Emma joins the lab as an ISMMS Master's student and brings experience in γδ T cell biology and mucosal immunology.
September 2025
We report in our latest publication in Mucosal Immunology that a unique microbiota that induces expansion of the γδ IEL compartment also upregulates CD39 expression through TCR and IL-15 signaling. Congratulations to Sara (along with Andrew, Jack and Alyssa) on a fantastic story!
August 2025
Our latest publication in Science Immunology shows that multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis. Congrats to Weili and Natasha (with an assist from Irving) on their hard work!
March 21, 2025
We're ready to rally and be part of the large movement to ensure that biomedical research continues to thrive in the United States. Come join us in Washington Square Park and show your support of NIH, CDC, NSF and the other government agencies that fund the basic science research that is fundamental to human health!
March 7, 2025