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Edelblum Lab

 IBD research laboratory at Mount Sinai School of Medicine studying immune/epithelial interactions to better understand the underlying causes of Crohn's disease and discover potential new areas for therapeutic development

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3.1 million Americans

LIVE WITH INFLAMMATORY BOWEL DISEASE

Crohn's disease and ulcerative colitis affect 1.3% of the population with 70,000 new cases diagnosed every year. IBD is caused by a combination of genetic and environmental factors that lead to an abnormal immune reaction to the normal bacteria found in the intestine.

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We report in our latest publication in Mucosal Immunology  that a unique microbiota that induces expansion of the γδ IEL compartment also upregulates CD39 expression through TCR and IL-15 signaling. Congratulations to Sara (along with Andrew, Jack and Alyssa) on a fantastic story! 

August 2025

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We are looking for a recent PhD graduate with experience in T cell biology or GI mucosal immunology to join our group! This is an NIH funded position focused on the role of IELs in Crohn's disease. Expertise in high-dimensional flow cytometry strongly preferred.

August 2025

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We are deeply saddened to learn of Alyssa Lillian's passing. Affectionately known as 'A2' when we were fortunate enough to have two Alyssas in the lab during Summer 2021, we were struck by Alyssa's love of medicine, her resilience and delightful sense of humor. She will be missed by those of us lucky enough to work with her during her time at Rutgers NJMS. Please consider donating to The Rose Fund set up in her memory that will support Child Life initiatives at Johns Hopkins.

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Our latest publication in Science Immunology  shows that multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis. Congrats to Weili and Natasha (with an assist from Irving) on their hard work!

March 21, 2025

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Sara gave a stellar defense and capped off an amazing run of Rutgers Ph.D. students in the lab!

March 18, 2025

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We're ready to rally and be part of the large movement to ensure that biomedical research continues to thrive in the United States. Come join us in Washington Square Park and show your support of NIH, CDC, NSF and the other government agencies that fund the basic science research that is fundamental to human health!

March 7, 2025

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Copyright 2017 Karen Edelblum

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